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Public product evidence543 certificate records mentioning this compound or product name301 provider-linked · 456 exact product matches

Status

Research Market

This name primarily lives in the research market and should not be read like an approved pharmaceutical product.

Research area

Longevity research

Primary research area: Longevity. Also surfaces under Metabolic for browsing and discovery.

Aliases

MOTS-c Peptide

Signal depth

Medium

No FDA label signal · 8 trials · 253 PubMed results

Promising

Research evidence

MOTS-c has name-matched human trials with published or reported controlled evidence, but is not FDA-approved. The research is real and ongoing — treat findings as developing rather than settled.

MOTS-c has 3 name-matched clinical trials (highest phase: Phase 2) and 253 PubMed-indexed publications and is not FDA-approved. Human trials are registered but none have posted results yet. Note: 1 retracted publication in the literature.

⚠ 1 retracted publication

Human data

Phase 2

Trial quality

Randomized

Outcomes

Clinical outcomes

Replication

Multiple trials

Literature

Top-tier journals

PHASE2 · RandomizedMOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity TrialPlatelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD NA · RandomizedComparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation Cell Metabolism · 741 citationsThe Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance Cell Metabolism · 309 citationsThe Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress PubMed · 197 citationsMOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.

Evidence history

Re-checked nightly against the registries — tracked since 2026-07-09. No band changes yet.

Grades evidence strength, not efficacy or safety. Research-use context; not medical advice. Graded 2026-09-08 from PubMed, ClinicalTrials.gov, ISRCTN, openFDA, Health Canada, and OpenAlex — computed deterministically and refreshed nightly, with a retraction check. How we grade →

What MOTS-c is

MOTS-c is a mitochondria-derived peptide that appears in metabolic-health, exercise-response, and longevity-oriented research discussions.

Why it matters

It is one of the most recognizable names in the peptide-longevity crossover category and shows how anti-aging marketing often borrows from metabolic research.

Regulatory context

MOTS-c is not FDA approved in the United States and is best understood as a research-market profile.

Practical reading note

The most useful way to read MOTS-c is as a research-interest compound, not as an established anti-aging intervention.