Immune Research Market

Vilon

A synthetic dipeptide (Lys-Glu) from the Khavinson bioregulator family, studied for thymic and immune system bioregulation and geroprotective effects.

ImmuneThymusBioregulatorKhavinson

Also referenced as: KE, Lys-Glu

Also appears in: Longevity

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9 tracked offers across 9 vendors · 4 dosages
Best trust-adjusted value: Peptide Supply Co · Strong trust · $1.89/mg
From
$1.89/mg
Status
Research Market

This name primarily lives in the research market and should not be read like an approved pharmaceutical product.

Category
Immune

Primary lane: Immune. Also surfaces under Longevity for browsing and discovery.

Aliases
2

KE, Lys-Glu

Signal depth
Medium

FDA label signal · 748 trials · 4709 PubMed results

Preclinical
Research evidence

Current evidence for Vilon is limited to laboratory or animal studies — there are no name-matched human trials with reported results. Any claims about effects in people are not yet backed by clinical data.

Vilon has no clinical trials that name it and 4709 PubMed-indexed publications and is not FDA-approved. Current evidence is preclinical or mechanistic.

Human data
Lab / animal only
Trial quality
No human trials
Outcomes
No human trials
Replication
Multiple papers
Literature
Established
Journal of Agricultural and Food Chemistry · 107 citations An Exploration of the Calcium-Binding Mode of Egg White Peptide, Asp-His-Thr-Lys-Glu, and In Vitro Calcium Absorption Studies of Peptide–Calcium Complex Journal Article Ontogenetic characterization of Phytoseius huaxiensis (Acari: Phytoseiidae). Journal Article Erratum: KAI WANG, FU SHU, LING LI, WEN-JIE DONG, HAO-NAN MU, MING SU, WEN-BO ZHU, MENG-FEI ZHANG, KE-JI GUO & JING CHE (2025) A New Cryptic Species of Calotes (Reptilia: Squamata: Agamidae) from Southeastern Xizang Autonomous Region, China. Zootaxa, 5609 (2), 275-285. Journal Article Impact of obesity and type 2 diabetes on muscle power, quality, and force-velocity, and their relation to functional capacity. Journal Article Kansei Engineering in the Evolving Service Sector: A Decade of Insights. Journal Article Intraoperative dexmedetomidine reduces postoperative sleep disturbance in older adults undergoing major abdominal surgery: a single-center, randomized, double-blind, placebo-controlled trial.
Evidence history

Re-checked nightly against the registries — tracked since 2026-07-09. No band changes yet.

Grades evidence strength, not efficacy or safety. Research-use context; not medical advice. Graded 2026-07-13 from PubMed, ClinicalTrials.gov, ISRCTN, openFDA, Health Canada, and OpenAlex — computed deterministically and refreshed nightly, with a retraction check. How we grade →

What is Vilon?

Vilon is a synthetic dipeptide with the sequence Lys-Glu (KE), the shortest peptide in the Khavinson bioregulator family. It is classified as a thymus and immune system bioregulator. Despite being only two amino acids, the Khavinson group proposes it has tissue-specific biological activity.

How it works

  • Immune modulation — Vilon is theorized to support thymic function and T-lymphocyte maturation through tissue-specific gene regulation (Khavinson et al., Bulletin of Experimental Biology and Medicine, 2011)
  • Geroprotective effects — in the Khavinson framework, KE dipeptide is proposed to interact with DNA in thymocytes and modulate gene expression relevant to immune senescence (Khavinson, Gerontology, 2005)
  • Thymic involution — the thymus progressively atrophies with age; Vilon is theorized to counteract this process, though direct evidence is limited to cell culture and animal studies from the Khavinson group

Research status

  • Khavinson (2005) reviewed peptide bioregulators including the KE dipeptide (Gerontology, 51(2):70–75)
  • Khavinson et al. (2002) reported effects of short peptides on thymocyte chromatin in aging (Bulletin of Experimental Biology and Medicine, 133(5):473–475)
  • No independent Western replication studies or clinical trials

Key considerations

  • The smallest Khavinson bioregulator — only 2 amino acids, raising questions about specificity and mechanism
  • Part of the same bioregulator family as Thymalin (the full thymic extract) and Thymagen
  • Available from research vendors as lyophilized powder or capsules