Immune Research Market

Thymagen

A synthetic dipeptide (Glu-Trp) from the Khavinson bioregulator family, studied for thymic bioregulation and immune system support in aging.

ImmuneThymusBioregulatorKhavinson

Also referenced as: EW, Glu-Trp, Thymogen

Also appears in: Longevity

Price compare
6 tracked offers across 6 vendors · 5 dosages
Best trust-adjusted value: Mile High Compounds · Light trust · $1.10/mg
From
$1.10/mg
Status
Research Market

This name primarily lives in the research market and should not be read like an approved pharmaceutical product.

Category
Immune

Primary lane: Immune. Also surfaces under Longevity for browsing and discovery.

Aliases
3

EW, Glu-Trp, Thymogen

Signal depth
Medium

No FDA label signal · 207 trials · 3160 PubMed results

Preclinical
Research evidence

Current evidence for Thymagen is limited to laboratory or animal studies — there are no name-matched human trials with reported results. Any claims about effects in people are not yet backed by clinical data.

Thymagen has no clinical trials that name it and 3160 PubMed-indexed publications and is not FDA-approved. Current evidence is preclinical or mechanistic.

Human data
Lab / animal only
Trial quality
No human trials
Outcomes
No human trials
Replication
Multiple papers
Literature
Established
Journal of Agricultural and Food Chemistry · 47 citations Whey Protein Peptide Pro-Glu-Trp Ameliorates Hyperuricemia by Enhancing Intestinal Uric Acid Excretion, Modulating the Gut Microbiota, and Protecting the Intestinal Barrier in Rats Hypertension · 31 citations Mechanism of angiotensin I converting enzyme inhibition by SQ20,881 (less than Glu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro) in vivo. Further evidence for extrapulmonary conversion. Biochemical and Biophysical Research Communications · 27 citations Isolation of the neuropeptide <Glu-Trp-Leu-Lys-Gly-Arg-Phe-NH2 (Pol-RFamide II) from the hydromedusa Polyorchis penicillatus Journal Article Eerdun Wurile, a Mongolian medicine, alleviates neuronal damage and improves neurological dysfunction after cerebral hemorrhage by activating the PI3K/AKT signaling pathway. Journal Article Integrated soil fertility assessment system for tobacco cultivation: A case study in Honghe prefecture. Journal Article Optical Coherence Tomography-Derived Excavation Index and Structure-Function Damage in Glaucoma.
Evidence history

Re-checked nightly against the registries — tracked since 2026-07-09. No band changes yet.

Grades evidence strength, not efficacy or safety. Research-use context; not medical advice. Graded 2026-07-13 from PubMed, ClinicalTrials.gov, ISRCTN, openFDA, Health Canada, and OpenAlex — computed deterministically and refreshed nightly, with a retraction check. How we grade →

What is Thymagen?

Thymagen (also marketed as Thymogen) is a synthetic dipeptide with the sequence Glu-Trp (EW), classified as a thymic bioregulator within the Khavinson peptide framework. It is related to Thymalin (the full thymic extract) and Vilon (KE dipeptide) but uses a different amino acid pair proposed to have overlapping thymic effects.

How it works

  • Thymic support — proposed to modulate gene expression in thymic epithelial cells, supporting T-lymphocyte maturation and thymic function during aging (Khavinson et al., Bulletin of Experimental Biology and Medicine, 2011)
  • Immune reconstitution — Thymogen has been studied in the context of immunodeficiency states and post-radiation immune recovery in Russian clinical literature

Research status

  • Thymogen (the EW dipeptide) has Russian regulatory approval as an immunomodulator (nasal spray formulation)
  • Morozov & Khavinson (1997) reviewed the immunomodulatory effects of thymic peptide preparations (Immunology Letters, 55(1):1–4)
  • Khavinson (2005) included Thymagen in the broader bioregulator review (Gerontology, 51(2):70–75)
  • Clinical data exists primarily in Russian-language literature

Key considerations

  • One of the few Khavinson bioregulators with any form of regulatory approval (Russian market)
  • Overlaps functionally with Vilon (KE) and Thymalin — all three target thymic/immune function
  • Available from research vendors as lyophilized powder, capsules, or nasal spray
  • The EW dipeptide has slightly more published clinical data than most other Khavinson short peptides