Weight loss Investigational

Peptide YY

A satiety-linked gut hormone that has long been studied in obesity and appetite regulation.

Gut HormoneSatietyObesityInvestigational

Also referenced as: PYY, PYY3-36

Also appears in: Hormone

Public product evidence No certificate records are bound to a tracked Peptide YY product page A record counts here only when a vendor publishes a certificate against one of its own tracked Peptide YY product pages. Other certificates naming this compound may still exist — search the wider certificate database.
Status
Investigational

This compound has a genuine development or study trail, but it is not an approved routine drug.

Research area
Weight-loss / incretin research

Primary research area: Weight loss. Also surfaces under Hormone for browsing and discovery.

Body systems
Hormones · Gut

Where the compound acts, as a browse axis. It is an editorial grouping for discovery, not a claim about labeled indications.

Aliases
2

PYY, PYY3-36

Signal depth
Medium

No FDA label signal · 720 trials · 4434 PubMed results

Preclinical
Research evidence

Current evidence for Peptide YY is limited to laboratory or animal studies — there are no name-matched human trials with reported results. Any claims about effects in people are not yet backed by clinical data.

Peptide YY has 2 name-matched clinical trials (highest phase: no phased trial) and 4434 PubMed-indexed publications and is not FDA-approved.

Human data
Human (non-phased)
Trial quality
Randomized
Outcomes
Clinical outcomes
Replication
Meta-analysis
Literature
Top-tier journals
NA · Randomized The Comparison of PYY, Ghrelin, GLP1, Glucose Level, Level of Satiety, and Ad Libitum Intake in Obese and Non-Obese Patients After Breakfast With Balanced Macronutrient Composition Trial APPETITE: linguAl PYY3-36 on aPpEtite and acuTe Energy InTakE Nature · 2,394 citations Gut hormone PYY3-36 physiologically inhibits food intake Nature · 2,269 citations Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide New England Journal of Medicine · 1,635 citations Inhibition of Food Intake in Obese Subjects by Peptide YY 3–36 Journal Article A Nature-Derived Peptide Promotes Satiety Hormone Response and Weight Loss In Vivo.
Evidence history
  1. 2026-11-07 Promising → Preclinical Band Promising → Preclinical; -8 trials; +1 PubMed
  2. 2026-11-06 Early → Promising Band Early → Promising; -7 trials; +1 PubMed
  3. 2026-11-01 Preclinical → Early Band Preclinical → Early; +22 trials; +3 PubMed
  4. 2026-10-17 Promising → Preclinical Band Promising → Preclinical
  5. 2026-10-15 Preclinical → Promising Band Preclinical → Promising
  6. 2026-10-10 Early → Preclinical Band Early → Preclinical; -7 trials; +2 PubMed
  7. 2026-10-08 Promising → Early Band Promising → Early; +1 PubMed
  8. 2026-10-03 Early → Promising Band Early → Promising; +8 trials
  9. 2026-10-02 Promising → Early Band Promising → Early; +1 PubMed
  10. 2026-09-30 Early → Promising Band Early → Promising; +7 trials
  11. 2026-09-26 Promising → Early Band Promising → Early; -22 trials
  12. 2026-09-22 Preclinical → Promising Band Preclinical → Promising; -8 trials
  13. 2026-09-19 Promising → Preclinical Band Promising → Preclinical; +8 trials; +1 PubMed
  14. 2026-09-18 Early → Promising Band Early → Promising; -8 trials
  15. 2026-09-17 Promising → Early Band Promising → Early; +22 trials; +2 PubMed
  16. 2026-09-16 Early → Promising Band Early → Promising; -22 trials

Grades evidence strength, not efficacy or safety. Research-use context; not medical advice. Graded 2026-11-08 from PubMed, ClinicalTrials.gov, ISRCTN, openFDA, Health Canada, and OpenAlex — computed deterministically and refreshed nightly, with a retraction check. How we grade →

What peptide YY is

Peptide YY, often shortened to PYY, is a satiety-linked gut hormone involved in appetite regulation.

Why it matters

PYY belongs in any serious obesity-peptide library because it is part of the physiological foundation behind modern appetite-control pharmacology.

Regulatory context

Peptide YY is not FDA approved as a standard peptide therapy in the United States.

Practical reading note

PYY is one of those peptides that matters scientifically even when later drug development ends up using more stable analogs or combinations instead of the native hormone itself.