Weight Loss Investigational

Peptide YY

A satiety-linked gut hormone that has long been studied in obesity and appetite regulation.

Gut HormoneSatietyObesityInvestigational

Also referenced as: PYY, PYY3-36

Also appears in: Hormone

Status
Investigational

This compound has a genuine development or study trail, but it is not an approved routine drug.

Category
Weight Loss

Primary lane: Weight Loss. Also surfaces under Hormone for browsing and discovery.

Aliases
2

PYY, PYY3-36

Signal depth
Medium

No FDA label signal · 708 trials · 4377 PubMed results

Promising
Research evidence

Peptide YY has name-matched human trials with published or reported controlled evidence, but is not FDA-approved. The research is real and ongoing — treat findings as developing rather than settled.

Peptide YY has 3 name-matched clinical trials (highest phase: Phase 2) and 4377 PubMed-indexed publications and is not FDA-approved. Human trials are registered but none have posted results yet.

Human data
Phase 2
Trial quality
Large RCT
Outcomes
Clinical outcomes
Replication
Meta-analysis
Literature
Top-tier journals
PHASE2 · Randomized A Study of Nasal PYY3-36 and Placebo for Weight Loss in Obese Subjects PHASE1/PHASE2 · Randomized Inhibition of Food Intake in Response to Oral GLP-1 and Peptide YY3-36 NA · Randomized The Role of Peptide YY (PYY)in Inhibiting Food Intake. Nature · 2,330 citations Gut hormone PYY3-36 physiologically inhibits food intake Nature · 2,278 citations Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide New England Journal of Medicine · 1,584 citations Inhibition of Food Intake in Obese Subjects by Peptide YY<sub>3–36</sub>
Evidence history

Re-checked nightly against the registries — tracked since 2026-07-09. No band changes yet.

Grades evidence strength, not efficacy or safety. Research-use context; not medical advice. Graded 2026-07-13 from PubMed, ClinicalTrials.gov, ISRCTN, openFDA, Health Canada, and OpenAlex — computed deterministically and refreshed nightly, with a retraction check. How we grade →

What peptide YY is

Peptide YY, often shortened to PYY, is a satiety-linked gut hormone involved in appetite regulation.

Why it matters

PYY belongs in any serious obesity-peptide library because it is part of the physiological foundation behind modern appetite-control pharmacology.

Regulatory context

Peptide YY is not FDA approved as a standard peptide therapy in the United States.

Practical reading note

PYY is one of those peptides that matters scientifically even when later drug development ends up using more stable analogs or combinations instead of the native hormone itself.