Anti-Aging Research Market

MOTS-c

A mitochondria-derived peptide studied in metabolic and exercise-related aging discussions.

MitochondriaMetabolismResearch Market

Also referenced as: MOTS-c Peptide

Also appears in: Weight Loss

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135 tracked offers across 135 vendors · 19 dosages
Best trust-adjusted value: Peptide Plugs · Strong trust · $0.30/mg
From
$0.30/mg
Status
Research Market

This name primarily lives in the research market and should not be read like an approved pharmaceutical product.

Category
Anti-Aging

Primary lane: Anti-Aging. Also surfaces under Weight Loss for browsing and discovery.

Aliases
1

MOTS-c Peptide

Signal depth
Medium

No FDA label signal · 8 trials · 246 PubMed results

Promising
Research evidence

MOTS-c has name-matched human trials with published or reported controlled evidence, but is not FDA-approved. The research is real and ongoing — treat findings as developing rather than settled.

MOTS-c has 3 name-matched clinical trials (highest phase: Phase 2) and 246 PubMed-indexed publications and is not FDA-approved. Human trials are registered but none have posted results yet. Note: 1 retracted publication in the literature.

⚠ 1 retracted publication
Human data
Phase 2
Trial quality
Randomized
Outcomes
Clinical outcomes
Replication
Multiple trials
Literature
Top-tier journals
PHASE2 · Randomized MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity Trial Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD NA · Randomized Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation Cell Metabolism · 725 citations The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance Cell Metabolism · 297 citations The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress PubMed · 184 citations MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.
Evidence history

Re-checked nightly against the registries — tracked since 2026-07-09. No band changes yet.

Grades evidence strength, not efficacy or safety. Research-use context; not medical advice. Graded 2026-07-13 from PubMed, ClinicalTrials.gov, ISRCTN, openFDA, Health Canada, and OpenAlex — computed deterministically and refreshed nightly, with a retraction check. How we grade →

What MOTS-c is

MOTS-c is a mitochondria-derived peptide that appears in metabolic-health, exercise-response, and longevity-oriented research discussions.

Why it matters

It is one of the most recognizable names in the peptide-longevity crossover category and shows how anti-aging marketing often borrows from metabolic research.

Regulatory context

MOTS-c is not FDA approved in the United States and is best understood as a research-market profile.

Practical reading note

The most useful way to read MOTS-c is as a research-interest compound, not as an established anti-aging intervention.