Other Investigational

Cortistatin

A neuropeptide related to somatostatin that has been studied for anti-inflammatory, neuroendocrine, and cardiovascular effects.

NeuropeptideImmuneInflammationInvestigational

Also referenced as: CST

Also appears in: Hormone · Immune

Status
Investigational

This compound has a genuine development or study trail, but it is not an approved routine drug.

Category
Other

Primary lane: Other. Also surfaces under Hormone, Immune for browsing and discovery.

Aliases
1

CST

Signal depth
Medium

No FDA label signal · 727 trials · 8042 PubMed results

Preclinical
Research evidence

Current evidence for Cortistatin is limited to laboratory or animal studies — there are no name-matched human trials with reported results. Any claims about effects in people are not yet backed by clinical data.

Cortistatin has no clinical trials that name it and 8043 PubMed-indexed publications and is not FDA-approved. Current evidence is preclinical or mechanistic.

Human data
Lab / animal only
Trial quality
No human trials
Outcomes
No human trials
Replication
Multiple papers
Literature
Top-tier journals
Arthritis Care & Research · 462 citations Measures of physical performance assessments: Self‐Paced Walk Test (SPWT), Stair Climb Test (SCT), Six‐Minute Walk Test (6MWT), Chair Stand Test (CST), Timed Up & Go (TUG), Sock Test, Lift and Carry Test (LCT), and Car Task Nature · 448 citations 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in Nature · 362 citations The human CST complex is a terminator of telomerase activity Journal Article Physics-informed-GPR data augmentation framework for flower-shaped antenna performance optimization and prediction using machine learning models. Journal Article Mental tasks induce common modulations of oscillations in cortex and spinal cord. Journal Article Biomechanical performance of expanded polytetrafluorethylene sutures, flanged polyvinylidene fluoride and polypropylene in scleral IOL fixation.
Evidence history

Re-checked nightly against the registries — tracked since 2026-07-09. No band changes yet.

Grades evidence strength, not efficacy or safety. Research-use context; not medical advice. Graded 2026-07-13 from PubMed, ClinicalTrials.gov, ISRCTN, openFDA, Health Canada, and OpenAlex — computed deterministically and refreshed nightly, with a retraction check. How we grade →

What cortistatin is

Cortistatin is a neuropeptide related to somatostatin with research relevance in inflammation, neuroendocrine signaling, and cardiovascular biology.

Why it matters

It is a good example of a peptide that is scientifically interesting and biologically rich even though it is not a mainstream vendor-market name.

Regulatory context

Cortistatin is not FDA approved as a therapeutic peptide in the United States.

Practical reading note

Adding peptides like cortistatin helps keep the library from becoming only a catalog of the internet’s loudest compounds.